In A Study Of The Alzheimer’S Disease There Is A New Discovery – Part 3 of 3
Carrillo noted that these results also confirm that the disease starts developing 10 to 15 years before it is diagnosed. This understanding could precede to new ways of diagnosing and treating the illness. “Perhaps future therapeutics attacking oligomers instead of plaques would be a strategy”.
One expert did have some reservations about that possibility, however. “The larger ambivalent issue is how these oligomers relate to people where plaques accumulate many years prior to disease onset,” said Greg M Cole, professor of medicine and neurology and associate director of the UCLA Alzheimer’s Center. “One would anticipate the little oligomer aggregates to arise prior to the bigger plaque aggregates, that is, decades before important memory problems surface”.
That could mean that “targeting oligomers may travail best for prevention,” rather than the treatment of existing disease. “Ongoing efforts to track and specifically target the oligomers in clinical trials with memory deficit patients should soon tell us how much good we can do hitting the oligomers. It may be a whopping success or too little, too late”.