The Genetic Sequence, Which Is Responsible For The Occurrence Of Medulloblastoma In Children – Part 1 of 3
The Genetic Sequence, Which Is Responsible For The Occurrence Of Medulloblastoma In Children. US scientists have unraveled the genetic jurisprudence for the most customary type of brain cancer in children. Gene sequencing reveals that this tumor, medulloblastoma, or MB, possesses far fewer genetic abnormalities than comparable adult tumors. The discovery that MB has five to 10 times fewer mutations than stable adult tumors could further attempts to understand what triggers the cancer and which treatment is most effective.
And “The good news here is that for the first time now we’ve identified the debilitated genetic pieces in a pediatric cancer, and found that with MD there are only a few broken parts,” said lead author Dr Victor E Velculescu, associate professor with the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University in Baltimore. “And that means it’s potentially easier to elapse and to stop it,” he said, likening the cancer to a train that’s speeding out of control. Velculescu and his colleagues, who circulate their findings in the Dec 16, 2010 online issue of Science, say this is the first time genetic decoding has been applied to a non-adult cancer.
Each year this cancer strikes about 1 in every 200000 children younger than 15 years old. Before migrating through the patient’s dominant nervous system, MBs begin in the cerebellum portion of the brain that is chief for controlling balance and complicated motor function. Focusing on 88 childhood tumors, the research team uncovered 225 tumor-specific mutations in the MB samples, many fewer than the number found in of age tumors.