Correlation Use Drugs For Heartburn And The Percentage Of Birth Defects Of Children – Part 3 of 3
A consanguineous journal editorial, written by Dr Allen A Mitchell, director of the Slone Epidemiology Center at Boston University School of Medicine, also noted some caveats. These included the truth that even this big of a sample may not have been large enough to detect specific birth defects (such as heart defects) or to ascertain the effect of specific drugs within the class. Nor can the influence of other factors be ruled out. Perhaps folic-acid supplementation during pregnancy is hiding the unswerving effects of the PPIs.
The bottom line, according to the experts, is that it’s still not clear whether these drugs are safe or not for pregnant women. “Having negative observations is never unconditionally reassuring. All you can say is that within that range in this case, 800000 infants, the probability is that it is safe. The balance in pragmatic terms is how important is it to treat the symptoms that any drug is designed to treat versus the safeness of pregnancy. That’s a very difficult decision to make”.