Amphotericin B And Flucytosine For Antifungal Therapy – Part 1 of 3
Amphotericin B And Flucytosine For Antifungal Therapy. A analgesic regimen containing two powerful antifungal medicines – amphotericin B and flucytosine – reduced the hazard of dying from cryptococcal meningitis by 40 percent compared to treatment with amphotericin B alone, according to new research in April 2013. The study also found that those who survived the disorder were less likely to be disabled if they received treatment that included flucytosine. “Combination antifungal therapy with amphotericin and flucytosine for HIV-associated cryptococcal meningitis significantly reduces the risk of dying from this disease,” said the study’s possibility author, Dr Jeremy Day, head of the CNS-HIV Infections Group for the Wellcome Trust Major Overseas Program in Vietnam. “This combination could save 250000 deaths across Africa and Asia each year.
The tenor to achieving this will be improving access to the antifungal agent flucytosine,” said Day, also a research lecturer at the University of Oxford. Flucytosine is more than 50 years primordial and off patent, according to Day. The drug has few manufacturers, and it isn’t licensed for use in many of the countries where the burden from this disease is highest.
Where it is available, the limited supply often drives the cost higher. “We count the results of this study will help drive increased and affordable access to both amphotericin and flucytosine. Infectious disease specialist Dr Bruce Hirsch, an attending physician at North Shore University Hospital in Manhasset, NY, said that in the United States, “the use of these medicines, amphotericin and flucytosine, is the usual touchstone of care for this dangerous infection, and is followed by long-term treatment with fluconazole another antifungal”.