Amphotericin B And Flucytosine For Antifungal Therapy – Part 3 of 3
The current study included 299 people with cryptococcal meningitis who were randomly assigned to one of three treatment regimens: amphotericin B unequalled for four weeks; amphotericin B plus flucytosine for two weeks; or amphotericin B plus fluconazole for two weeks. People in the second and third groups were also given eight weeks of reinforcement therapy with fluconazole. The investigators found that combination therapy with amphotericin B and flucytosine resulted in a 40 percent lower risk of death compared to amphotericin therapy alone.
Combination group therapy with fluconazole didn’t appear to affect survival rates, according to the study. The combination therapy with flucytosine also resulted in lower levels of Cryptococcus in the spinal fluid, according to the study. Side slang shit were similar in all three treatment regimens. Possible side effects are anemia, low levels of potassium, low white blood cell counts and additional infections, the study authors noted.
This contemplate is the first ever to demonstrate that a combination of antifungal drugs can significantly reduce the risk of death from this disease,” Day pointed out. The reason for the success of this particular combination is that it hastily kills Cryptococcus, according to the author of an accompanying editorial, Dr John Perfect, of Duke University Medical Center in Durham, NC “In cryptococcal meningitis, the principle is set: the hasty killing of yeasts at the site of infection translates into a better outcome. Long-term success in the treatment of cryptococcal meningitis depends on how well we kill yeasts with the initial treatment regimen uzma ki gol gand men lun. The study, which was funded by the Wellcome Trust and the British Infection Society, is published in the April, 4 2013 son of the New England Journal of Medicine.