The Genetic History Of The Father Also Affect Cancers Of Female Organs – Part 1 of 3
The Genetic History Of The Father Also Affect Cancers Of Female Organs. Women with female relatives who have had bust or ovarian cancer are often acutely posted of their own increased risk and may seek genetic counseling. But they should also pay attention to their father’s family history, one genetic counselor warns. The inherited genetic predisposition to core and ovarian cancer is mostly caused by a mutation in one or both of the BRCA1 or BRCA2 tumor suppressor genes, said Jeanna McCuaig, a genetic counselor at Princess Margaret Hospital in Toronto.
And, she unmistakeable out, “if your mom or your dad has a BRCA1 or BRCA2 mutation, you would have a 50 percent chance of inheriting it from either one”. That explains why a father’s family history is as important to consider as a mother’s. “Anecdotally, I’ve had patients come in and say, ‘I never concern about my dad’s side,'” McCuaig said. She decided to do some research into the implications of that statement. “We took two years of serene charts referred to our clinic, referred as new patients, and looked to see how many had relatives with breast or ovarian cancers on the mom’s side versus the dad”.
She found that patients who came to her Familial Breast and Ovarian Cancer Clinic at the sickbay were more than five times more likely to be referred with a maternal family history of breast or ovarian cancer than a paternal history of such cancers. To get the word out, she wrote a commentary on the subject, published online in The Lancet Oncology.